January 27, 2023

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Sana Biotechnology will cut 15% of its workforce in latest layoffs affecting Seattle companies – GeekWire

(Sana Picture)

Seattle-dependent cell and gene remedy firm Sana Biotechnology will decrease its workforce by 15%, according to a assertion issued Tuesday.

The business reported it was shutting a plan focused on heart failure and outlined reset priorities for other plans. The layoffs will be total by the end of the calendar year, according to an SEC submitting.

Among 75 to 80 personnel are impacted, Sana’s vice president of finance Nicole Keith instructed GeekWire. The business has functions in Seattle, South San Francisco and Cambridge, Mass.

“With these types of a various pipeline and broad possibilities introduced by our science and systems, portfolio prioritization is important, and we have taken techniques to keep in a place to seize the opportunities forward,” explained Keith in an electronic mail to GeekWire.

“This prioritization involves producing hard program and source selections, but it is the ideal way to maintain a route to people for our guide programs as we changeover to a scientific stage enterprise,” extra Keith.

Sana elevated $587 million in February 2021 when it went public in the biggest ever IPO for a preclinical phase biotech corporation. Sana now strategies to get its to start with possible therapy into medical demo following year with more to observe.

In its third quarter economic report the firm said it had $511.6 million in money, funds equivalents, and marketable securities on hand. The organization has sufficient cash runway to last into 2025, in accordance to Tuesday’s statement.

Sana joins a listing of other tech and daily life sciences businesses slicing headcount amid the broader marketplace downturn. Sana’s inventory is down far more than 70% this calendar year, trading at about $4.63 on Wednesday, down from a peak of $39.87 soon soon after its IPO.

“Losing proficient and valued colleagues is agonizing, and we thank them for their contributions to Sana’s mission,” explained Sana CEO Steve Harr in the assertion. “Prioritization is crucial, and we will continue on to make selections bsed on inner information, exterior evolution of the discipline, and the company’s wanted abilities,” he extra.

The biotech field boomed in the course of the pandemic but now faces a sluggish funding atmosphere and waning valuations. Adaptive Biotechnologies, Absci, and Zymeworks also introduced layoffs this year. Seattle startup TwinStrand Biosciences also reportedly laid off personnel.

This summertime, Sana announced programs to make an 80,000 sq. foot production facility in Bothell, Wash., resulting in $100 million in price savings above a previously preferred site in the San Francisco Bay Region. 

Sana expects to file its initial investigational new drug software (IND) this yr with the U.S. Food stuff and Drug Administration for a Motor vehicle T cellular therapy item, location the stage for a clinical trial. The treatment for B cell malignancies is an “off the shelf” product derived from donor cells (targeting a molecule identified as CD19). Information are envisioned in 2023.

Sana also outlined designs to file IND future calendar year for another Automobile T cell remedy item for B cell malignancies (focusing on CD22). And it aims to file an IND next 12 months for an experimental therapy that has the opportunity to create therapeutic cells inside the individual. The corporation also aims to file INDs for possible cellular remedies for sort 1 diabetic issues and several myeloma in 2024.